関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Bromo-1,1,1-trifluorobutane | HCID 521006 | — |
| 反応物 | 4-Chloro-6-(2-chloro-5-methylanilino)pyrimidine | HCID 18009138 | — |
| 反応物 | Isohexane ethyl acetate | HCID 21882781 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 4-Chloro-6-[N-(4,4,4-trifluorobutyl)-2-chloro-5-methylanilino]pyrimidine | HCID 18009133 | — |
反応手順
4-Chloro-6-(2-chloro-5-methylanilino)pyrimidine (Reference Example 12) (0.28 g, 1.1 mmol) and 1,1,1-trifluoro-4-bromobutane (0.32 g, 1.67 mmol) were dissolved in NMP (2 ml). Anhydrous potassium carbonate (0.31 g, 2.2 mmol) was added and the mixture heated to 50° C. for three hours. Following an aqueous work-up the product was obtained by column chromatography on silica gel using EtOAc-isohexane mixtures. (0.3 g, 75%). M/z 364 (MH)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06632820B1 |
|---|
| 出典データセット | uspto-grants-2003_10 |
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| ORD ID | ord-6c3abc9d8f7844c284714a36e889343f |
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| 出典メモ | uspto-grants-2003_10 |
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