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Potassium Carbonate → 4-Chloro-6-[N-(3-bromoallyl)-2-chloro-5-methylanilino]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,3-Dibromopropene | HCID 5201028 | — |
| 反応物 | 4-Chloro-6-(2-chloro-5-methylanilino)pyrimidine | HCID 18009138 | — |
| 反応物 | Isohexane ethyl acetate | HCID 21882781 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 4-Chloro-6-[N-(3-bromoallyl)-2-chloro-5-methylanilino]pyrimidine | HCID 73415729 | — |
反応手順
4-Chloro-6-(2-chloro-5-methylanilino)pyrimidine (Reference Example 12) (0.5 g, 1.97 mmol) and 1,3-dibromopropene [cis/trans mixture] (0.6 g, 3.0 mmol) were dissolved in NMP (2 ml). Anhydrous potassium carbonate (0.54 g, 4 mmol) was added and the mixture stirred at room temperature for seventeen hours. After aqueous work-up the product was obtained by column chromatography on silica gel using EtOAc/isohexane mixtures (0.68 g, 93%). M/z 372 (MH)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06632820B1 |
| 出典データセット | uspto-grants-2003_10 |
| ORD ID | ord-24a8e50c3f764c74a097464810f01362 |
| 出典メモ | uspto-grants-2003_10 |