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Methyl pyruvate → N-(3,4-methylenedioxyphenyl)alanine Iso-butyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl pyruvate | HCID 11748 | — |
| 反応物 | 1,3-Benzodioxol-5-amine | HCID 84310 | — |
| 反応物 | N-(3,4-methylenedioxyphenyl)alanine methyl ester | HCID 54531586 | — |
| 溶媒 | Isobutanol | HCID 6560 | — |
| 生成物 | N-(3,4-methylenedioxyphenyl)alanine Iso-butyl Ester | HCID 54134455 | — |
反応手順
Following reductive amination General Procedure AA above and using 3,4-methylenedioxyaniline (Aldrich) and methyl pyruvate (Aldrich), N-(3,4-methylenedioxyphenyl)alanine methyl ester was prepared. The methyl ester was then transesterified following General Procedure AQ above and using iso-butanol to provide the title compound as an oil. The reaction was monitored by silica gel tlc (Rf=0.61 in 25% EtOAc/hexanes). Purification was by preparative plate chromatography with silica gel using 25% EtOAc/hexanes as the eluant.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06632811B2 |
| 出典データセット | uspto-grants-2003_10 |
| ORD ID | ord-ad0a1bb8985b486c869bcd30354838bb |
| 出典メモ | uspto-grants-2003_10 |