Toluene → 4-Hydroxy-3-propoxybenzaldehyde

HRID 987870ノート

反応式

HRID 987870 の反応式
CC1(C)CO[CH:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([O:15][CH2:16][CH2:17][CH3:18])[CH:9]=2)[O:4]C1.C1(C)C=CC=CC=1>C(O)=O>[OH:14][C:11]1[CH:12]=[CH:13][C:8]([CH:5]=[O:4])=[CH:9][C:10]=1[O:15][CH2:16][CH2:17][CH3:18]

参加物

4

反応物 2

HCID 1140TolueneHCID 22987076HCID 22987076、化合物

生成物 1

HCID 17126234-Hydroxy-3-propoxybenzaldehyde収率 0.1%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

A mixture of 1.26 g (4.74 mmol) of 4-(5,5-dimethyl-1,3-dioxan-2-yl)-2-propoxyphenol, 20 ml of toluene and 20 ml of formic acid was vigorously stirred for 2 hours at room temperature. Thereafter, the reaction mixture was partitioned between toluene and water and the organic phase was washed several times with water, dried over magnesium sulfate, filtered and evaporated down. Crystallization of the residue from a mixture of 10 ml of diethyl ether and 20 ml of hexane gave 0.78 mg of 4-hydroxy-3-propoxybenzaldehyde.

後処理

  1. customThereafter, the reaction mixture was partitioned between toluene and water
  2. washthe organic phase was washed several times with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated down
  6. customCrystallization of the residue
  7. additionfrom a mixture of 10 ml of diethyl ether and 20 ml of hexane

出典と根拠

ORDレコード
ord-22979cd9413c4b5fa6b09df8a67e6f1c
出典データセット
uspto-grants-2003_10
特許番号
US06632909B2

反応ノート

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