Methyl chloroglyoxylate → HCID 513933、化合物

反応式

[NH2:1][C@@H:2]([CH2:27][C:28]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:31]=[CH:30][CH:29]=1)[C:3]([NH:5][CH2:6][CH2:7][CH2:8][C@H:9]([N:12]([S:17]([C:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH2:13][CH:14]([CH3:16])[CH3:15])[CH2:10][OH:11])=[O:4].Cl[C:39](=[O:44])[C:40]([O:42][CH3:43])=[O:41]>>[CH3:43][O:42][C:40](=[O:41])[C:39]([NH:1][C@H:2]([C:3](=[O:4])[NH:5][CH2:6][CH2:7][CH2:8][C@H:9]([N:12]([S:17]([C:20]1[CH:21]=[CH:22][C:23]([NH2:26])=[CH:24][CH:25]=1)(=[O:19])=[O:18])[CH2:13][CH:14]([CH3:16])[CH3:15])[CH2:10][OH:11])[CH2:27][C:28]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:31]=[CH:30][CH:29]=1)=[O:44]

参加物

反応物 2

HCID 79846Methyl chloroglyoxylate

HCID 513930HCID 513930、化合物

生成物 1

HCID 513933HCID 513933、化合物

実験手順

The title compound was prepared from (2S,4S)-2-amino-N-{4-[(4-amino-benzenesulfonyl)-isobutyl-amino]-5-hydroxy-pentyl}-3-naphthalen-1-yl-propionamide (see example 8) as described in general procedure D using methyl chlorooxoacetate. The final product was obtained in 75% yield.

出典と根拠

ORDレコード: ord-d5d14df91f934595bab99bdafe52ab9f
出典データセット: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06632816B1

反応ノート

読み込み中…