Ethyl Acetate → (S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetamide
反応式
[C@]12(CS(O)(=O)=O)C(C)(C)C(CC1)CC2=O.[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C@H:23]([N:27]1[CH2:32][CH2:31][C:30]2[S:33][CH:34]=[CH:35][C:29]=2[CH2:28]1)[C:24]([NH2:26])=[O:25].C(OCC)(=O)C>O.C(=O)(O)[O-].[Na+]>[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C@H:23]([N:27]1[CH2:32][CH2:31][C:30]2[S:33][CH:34]=[CH:35][C:29]=2[CH2:28]1)[C:24]([NH2:26])=[O:25]参加物
5
実験手順
To the suspension of 1.8 g of (S)-(+)-(2-chloro-phenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl) acetamide (1S)-(+)-camphor-10-sulfonic acid salt in 100 mL water, 50 mL of sodium bicarbonate solution in water was added. After stirring the mixture, 150 mL ethyl acetate was added. The combined organic layers are distilled off to get title product. The amount of product obtained was 1 g (56%).