関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Estradiol | HCID 5757 | — |
| 反応物 | Norethisterone Acetate | HCID 5832 | — |
| 反応物 | 2-(2-Hydroxypropoxy)-1-propanol | HCID 32881 | — |
| 反応物 | Oleyl Alcohol | HCID 5284499 | — |
| 反応物 | HCID 178527255 | HCID 178527255 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Estradiol; Norethindrone Acetate | HCID 3045253 | — |
反応手順
An estradiol/norethindrone acetate pressure-sensitive adhesive matrix composition was prepared by combining 0.7 parts of estradiol and 3.0 parts of norethindrone acetate along with 3.0 parts of ethyl cellulose (Ethocele® 10, Dow Chemical Corp., Midland, Mich.) in 30.0 parts ethyl acetate, 15.0 parts of toluene and 10.0 parts isopropyl alcohol. Then 12.2 parts of a polyacrylate adhesive (DURO-TAIE® 87-2510; National Starch Company, Bridgewater, N.J.) and 109.2 parts of a polysiloxane adhesive (BIO-PSA® Q7-4603; Dow Corning Corp, Midland, Mich.) were added and thoroughly mixed. Finally 9.0 parts of dipropylene glycol and 6.0 parts oleyl alcohol were added and mixed thoroughly in an appropriate container until the mixture was completely homogenous. The resulting composition had the ingredient concentrations on a dry weight percent basis (i.e., after evaporation of volatile solvents) as shown below.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06638528B1 |
|---|
| 出典データセット | uspto-grants-2003_10 |
|---|
| ORD ID | ord-19b297349b4b464a94791fb9bf448537 |
|---|
| 出典メモ | uspto-grants-2003_10 |
|---|
