反応式
O.[Na+].[Cl-].CN1[C@@H]2C[C@@H:11]([O:13][C:14]([CH:16]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)CO)=[O:15])C[C@H]1CC2>>[C:14]([O:13][CH3:11])(=[O:15])[CH2:16][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:14][CH2:16][CH2:19][CH2:24][CH2:23][CH2:22][CH2:21][CH3:20]参加物
3
実験手順
Basal gastric acidity was determined by pyloric ligation under ether anaesthesia followed by gastric lavage with normal saline. Except for the control group, all the rats received 3 doses (1, 3 & 5 mg/kg) of the said compound and standard antagonist atropine (0.01, 0.05 & 0.1 mg/kg) subcutaneously 15 minutes prior to pyloric ligation. Three hours later the animals were killed and the stomach was tied at the oesophageal junction and removed. The contents were collected by cutting along the greater curvature and the free acidity was determined by titration against 0.01 normal NaOH using Topfers reagent as indicator.
後処理
- customThree hours
- customremoved
- customThe contents were collected
出典と根拠
- ORDレコード
- ord-a17a817f1e9a426993b4306d25f81cd1
- 出典データセット
- uspto-grants-2003_10
- 特許番号
- US06638546B2
関連ノート
読み込み中…