2-Benzyl-5-cyanomethyl-2,5-diazabicyclo[2.2.1]heptane → 2-Benzyl-5-(2-aminoethyl)-2,5-diazabicyclo[2.2.1]heptane

HRID 988956

反応式

HRID 988956 の反応式
[CH2:1]([N:8]1[CH2:13][CH:12]2[CH2:14][CH:9]1[CH2:10][N:11]2[CH2:15][C:16]#[N:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Ni].N>[CH2:1]([N:8]1[CH2:13][CH:12]2[CH2:14][CH:9]1[CH2:10][N:11]2[CH2:15][CH2:16][NH2:17])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 219636452-Benzyl-5-cyanomethyl-2,5-diazabicyclo[2.2.1]heptane

生成物 1

HCID 219636712-Benzyl-5-(2-aminoethyl)-2,5-diazabicyclo[2.2.1]heptane収率 85.8%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 222Ammonia溶媒

実験手順

A solution of 5.74 g (25.3 mmoles) of 140 and 50 mL of NH3 were hydrogenated with 2 g of Raney nickel in a steel autoclave at 100 bar H2 and 100° C. for 2 hours. The catalyst was filtered off with suction and the solution was evaporated and distilled using a bulb tube (boiling point: 135°-145° C. at 0.01 mbar): 5.02 g of 141 as a colorless oil (87% of the theoretical yield).

後処理

  1. filtrationThe catalyst was filtered off with suction
  2. customthe solution was evaporated
  3. distillationdistilled

出典と根拠

ORDレコード
ord-c68908c4903e46c8b58522e109f42e98
出典データセット
uspto-grants-2003_10
特許番号
US06638925B2

関連ノート

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