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Hydrochloric Acid → 4-Phenylcyclohexan-1-amine--hydrogen chloride (1/1)
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Phenylcyclohexanone oxime | HCID 343882 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Phenylcyclohexan-1-amine--hydrogen chloride (1/1) | HCID 201281 | 100% |
反応手順
A mixture of 1-(hydroxyimino)-4-phenylcyclohexane (17.4 mmol) and Raney Nickel (300 mg) in ethanol was hydrogenated (90 psi) at 50° C. for 40 hours. The mixture was filtered through a pad of Celite, washed with MeOH, and concentrated. The residue was dissolved in MeOH, treated with HCl (4 N in dioxane, 20 mmol), and concentrated to give 4-phenylcyclohexylamine hydrochloride (100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06638927B2 |
| 出典データセット | uspto-grants-2003_10 |
| ORD ID | ord-4b8b58b12c5641d1a30f2a7d77ccf4b7 |
| 出典メモ | uspto-grants-2003_10 |