反応式
[N:1]1[CH:6]=[CH:5][C:4]([S:7][CH2:8][C:9]2[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][CH:10]=2)=[CH:3][CH:2]=1.C1(N[C:23](=O)[O-:24])C=CC=CC=1.[CH3:26][O:27][C:28]1[CH:29]=[C:30]2[C:34](=[CH:35][C:36]=1[C:37]([F:40])([F:39])[F:38])[NH:33][CH2:32][CH2:31]2>>[CH3:26][O:27][C:28]1[CH:29]=[C:30]2[C:34](=[CH:35][C:36]=1[C:37]([F:40])([F:38])[F:39])[N:33]([C:23](=[O:24])[NH:13][C:12]1[CH:11]=[CH:10][C:9]([CH2:8][S:7][C:4]3[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=3)=[CH:15][CH:14]=1)[CH2:32][CH2:31]2参加物
4
実験手順
4-(Pyridin-4-ylthiomethyl)aniline (0.37 g, 1.71 mmol) was converted to the phenylcarbamate and treated with 5-methoxy-6-trifluoromethylindoline (D11) (0.37 g, 1.71 mmol) as in the method of Example 26 to give the title compound (0.5 g, 64%) as a white crystalline solid m.p. 174-5° C.
出典と根拠
- ORDレコード
- ord-342b1da1f8b54a13bce21db6ceb7dc27
- 出典データセット
- uspto-grants-2003_10
- 特許番号
- US06638953B2
関連ノート
読み込み中…