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p-Bromobenzyl chloride → 1-[4-(4-Bromo-benzyloxy)-benzyl]-pyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Bromobenzyl chloride | HCID 68528 | — |
| 反応物 | 4-(Pyrrolidin-1-ylmethyl)phenol | HCID 18771978 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-[4-(4-Bromo-benzyloxy)-benzyl]-pyrrolidine | HCID 10132336 | 57.9% |
反応手順
The mixture of 4-hydroxybenzyl-pyrrolidine (177 mg), 4-bromo-benzylchloride (205 mg), and t-Bu3ONa (192 mg) in ethanol (10 mL) was heated at 80° C. for overnight. Concentration and preparative TLC provided the title compound (200 mg). 1H NMR (400 MHz, CDCI3)δ7.50 (d, J=6.5 Hz, 2 H), 7.32 (d, J=6.5 Hz, 2 H), 7.25 (d, J=6.5 Hz, 2 H), 6.90 (d, J=6.5 Hz, 2 H), 2.84 (s, 2 H), 2.50 (m, 4 H), 1.42 (m, 4 H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06638967B2 |
| 出典データセット | uspto-grants-2003_10 |
| ORD ID | ord-08358f3cc91642efa4cf3897b399b0a9 |
| 出典メモ | uspto-grants-2003_10 |