Cefpodoxime → cefpodoxime sodium

HRID 989419ノート

反応式

HRID 989419 の反応式
C(C(CCCC)C([O-])=O)C.[Na+:11].[CH3:12][O:13][CH2:14][C:15]1[CH2:36][S:35][C@@H:18]2[C@H:19]([NH:22][C:23](/[C:25](/[C:29]3[N:33]=[C:32]([NH2:34])[S:31][CH:30]=3)=[N:26]\[O:27][CH3:28])=[O:24])[C:20](=[O:21])[N:17]2[C:16]=1[C:37]([OH:39])=[O:38]>CN(C)C(=O)C.CO>[CH3:12][O:13][CH2:14][C:15]1[CH2:36][S:35][C@@H:18]2[C@H:19]([NH:22][C:23](/[C:25](/[C:29]3[N:33]=[C:32]([NH2:34])[S:31][CH:30]=3)=[N:26]\[O:27][CH3:28])=[O:24])[C:20](=[O:21])[N:17]2[C:16]=1[C:37]([O-:39])=[O:38].[Na+:11]

参加物

5

反応物 2

HCID 6335986CefpodoximeHCID 23672331Sodium 2-ethylhexanoate

生成物 1

HCID 23669317cefpodoxime sodium収率 95%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 31374Dimethylacetamide溶媒

実験手順

2.03 g of sodium 2-ethylhexanoate was dissolved in a mixture of 12.5 ml of N,N-dimethylacetamide and 50 ml of methanol, 5.0 g of cefpodoxime (7-[2-(2-amino-4-thiazolyl)-(Z)-2-(methoxyimino)acetamido]-3-methoxymethyl -3-cephem-4-carboxylic acid) was added thereto, and the mixture was stirred at room temperature for 30 minutes. Then, methanol was removed under a reduced pressure and 50 ml of acetone was added thereto. The solution was stirred for 30 minutes and filtered. The filtered solid was washed with 50 ml of acetone and then with 30 ml of isopropyl ether, and vacuum-dried at room temperature to give 4.98 g of pale yellow cefpodoxime sodium salt (yield: 95%).

後処理

  1. additionwas added
  2. customThen, methanol was removed under a reduced pressure and 50 ml of acetone
  3. additionwas added
  4. stirringThe solution was stirred for 30 minutes
  5. filtrationfiltered
  6. washThe filtered solid was washed with 50 ml of acetone
  7. dry with materialwith 30 ml of isopropyl ether, and vacuum-dried at room temperature

出典と根拠

ORDレコード
ord-f6003448ddb3495688256b19219723b7
出典データセット
uspto-grants-2003_10
特許番号
US06639068B1

反応ノート

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