Ethyl Acetate → 1-(Ethoxycarbonyloxy)ethyl (1s,5r,6s)-2-(7-acetylimidazo[5,1-b]thiazol-2-yl)-6 ((1r)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate

温度

-10 °C

Sodium(1S,5R,6S)-2-(7-acetylimidazo[5,1-b]thiazol-2-yl)-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate (71.9 mg) was dissolved in 2.0 ml of DMF. 1-(Ethoxycarbonyloxy)ethyl iodide (66.3 mg) was added to the solution in an argon atmosphere at −20° C. The mixture was stirred for 2 hr while raising the temperature to −10° C. Ethyl acetate (20 ml) was added to the reaction solution. The mixture was extracted twice, followed by washing twice with 10 ml of semisaturated brine. The organic layer was dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under the reduced pressure to a volume of 2 ml. The residue was purified by column chromatography on silica gel (chloroform:methanol=15:1) and Sephadex LH-20 (dichloromethane:methanol=1:1) in that order to give 57.4 mg of the title compound.

1. extractionThe mixture was extracted twice
2. washby washing twice with 10 ml of semisaturated brine
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. filtrationfiltered
5. concentrationThe filtrate was concentrated under the reduced pressure to a volume of 2 ml
6. customThe residue was purified by column chromatography on silica gel (chloroform:methanol=15:1) and Sephadex

ORDレコード

ord-3629844f9aea4f06a590cfe4328aac5e

出典データセット

uspto-grants-2002_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06458780B1