化工社化工社 化学情報印刷レポート · 研究参考用
2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester → N-(4-Bromo-3-methyl-5-isoxazolyl)-2-(carbomethoxy)thiophene-3-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester | HCID 2736733 | — |
| 反応物 | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| 生成物 | N-(4-Bromo-3-methyl-5-isoxazolyl)-2-(carbomethoxy)thiophene-3-sulfonamide | HCID 10833686 | 73% |
反応手順
N-(4-Bromo-3-methyl-5-isoxazolyl)-2-(carbomethoxy)thiophene-3-sulfonamide was prepared in the same manner as described in Example 10 from 5-amino-4-bromo-3-methylisoxazole and 2-(carbomethoxy)thiophene-3-sulfonyl chloride in 73% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 198-200° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06458805B2 |
| 出典データセット | uspto-grants-2002_10 |
| ORD ID | ord-ffe307328f4b41e4be0a670278fe7ef9 |
| 出典メモ | uspto-grants-2002_10 |