化工社化工社 化学情報印刷レポート · 研究参考用
Anthranilic Acid → Benzoic acid, 2-(((4-methylphenyl)sulfonyl)amino)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Anthranilic Acid | HCID 227 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Benzoic acid, 2-(((4-methylphenyl)sulfonyl)amino)- | HCID 22763 | — |
反応手順
A solution of 3.45 g (25 mmol) of sodium carbonate and 1.0 g (7.3 mmol) of anthranilic acid in 50 ml of water at 60° was treated with 2.09 g (10.95 mmol) of p-toluenesulfonyl chloride and held at 70° for 30 min. The reaction mixture was cooled to ambient temperature and acidified with 10% HCl. After standing for 18 hr the product was collected by filtration, washed with water and dried to give N-4-methylphenylsulfonylanthranilic acid as a solid, mp 226-229°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06458845B1 |
| 出典データセット | uspto-grants-2002_10 |
| ORD ID | ord-8ea78ecd93754de4ba3e88942421c7d1 |
| 出典メモ | uspto-grants-2002_10 |