(+-)-3-Quinuclidinol → 1-(4,6-Diethoxy-1,3,5-triazin-2-yl)-3-hydroxyquinuclidinium chloride
反応式
[Cl:1][C:2]1[N:7]=[C:6]([O:8][CH2:9][CH3:10])[N:5]=[C:4]([O:11][CH2:12][CH3:13])[N:3]=1.[N:14]12[CH2:21][CH2:20][CH:17]([CH2:18][CH2:19]1)[CH:16]([OH:22])[CH2:15]2>>[Cl-:1].[CH2:12]([O:11][C:4]1[N:5]=[C:6]([O:8][CH2:9][CH3:10])[N:7]=[C:2]([N+:14]23[CH2:21][CH2:20][CH:17]([CH2:18][CH2:19]2)[CH:16]([OH:22])[CH2:15]3)[N:3]=1)[CH3:13]参加物
3
実験手順
The operation was carried out in the same manner as in Preparation Example 1 but using 4.07 g (0.02 mols) of a 2-chloro-4,6-diethoxy-1,3,5-triazine and 2.54 g (0.02 mols) of a 3-quinuclidinol to obtain 6.51 g (yield, 98.4%) of white crystals of a 1-(4,6-diethoxy-1,3,5-triazin-2-yl)-3-hydroxyquinuclidinium chloride represented by the following general formula (XII)
後処理
- customThe operation was carried out in the same manner as in Preparation Example 1
- customto obtain