5-Bromo-1-benzothiophene → 1-(5-Bromobenzo[b]thiophen-3-yl)ethanone

HRID 990804ノート

反応式

HRID 990804 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][CH:8]=[CH:7][C:6]=2[CH:10]=1.[C:11](C1C2C=CC=C(Br)C=2SC=1)(=[O:13])[CH3:12]>>[C:11]([C:7]1[C:6]2[CH:10]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=2[S:9][CH:8]=1)(=[O:13])[CH3:12]

参加物

3

反応物 2

HCID 27765785-Bromo-1-benzothiopheneHCID 184166863-Acetyl-7-bromo-benzo[b]thiophene

生成物 1

HCID 6178361-(5-Bromobenzo[b]thiophen-3-yl)ethanone収率 70%

実験手順

Prepared in 70% yield from 5-bromo-benzothiophene (See Ple, P. A.; Marnett, L. J. J. Heterocycl. Chem., vol. 25, pp. 1271-1272 (1988), incorporated herein by references), analogous to the procedure for the preparation of 3-acetyl-7-bromo-benzo[b]thiophene. 1H NMR (300 MHz, CDCl3) δ8.04 (d, H. J=1.8Hz), 7.86 (s, 1H), 7.74 (d, 1H, J=8.4Hz), 7.56 (dd, 1H, J=8.4, 1.8Hz), 2.67 (s, 3H). Anal. (C10H7BrOS) C, H, Br, S. Calculated C=47.07, H=2.77, Br=31.32, S=12.57; found C=47.18, H=2.76, Br=31.42, S=12.55.

出典と根拠

ORDレコード
ord-766f6c4b458b42d2b06e233cafbf66a1
出典データセット
uspto-grants-2002_10
特許番号
US06462069B2

反応ノート

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