Potassium Hydroxide → 1,3-Diphenyl-2-propyn-1-one

HRID 990890

反応式

HRID 990890 の反応式
[OH-].[K+].[CH:3]1[CH:8]=[CH:7][C:6](/[CH:9]=[C:10](\Br)/[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])=[CH:5][CH:4]=1>O.O.CC(C)=O>[CH:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 5383396alpha-Bromochalcone

生成物 1

HCID 976371,3-Diphenyl-2-propyn-1-one

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 18366337Propan-2-one--water (1/1)溶媒

実験手順

Potassium hydroxide (3.48 mmol), dissolved in water (0.87 M (4.0 ml)), is added over about 30 minutes to a refluxing solution of the alpha-bromochalcone (3.48 mmol) in 0.35 M of 1:1 water/acetone (5 ml each). After 20 minutes of further refluxing, the solution is cooled and diluted with water. The water is extracted with ether, which is dried with MgSO4 and evaporated. Chromatography on silica gel yielded 1,3-diphenylpropynone and its derivatives.

後処理

  1. temperaturethe solution is cooled
  2. extractionThe water is extracted with ether, which
  3. dry with materialis dried with MgSO4
  4. customevaporated

出典と根拠

ORDレコード
ord-a0b061284c2142e98e2b0253dcf35b88
出典データセット
uspto-grants-2002_10
特許番号
US06462075B1

関連ノート

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