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Isopropanol → 2-Chloro-6-(3-fluoro-phenyl-amino)-purine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 3-Fluoroaniline | HCID 9742 | — |
| 反応物 | 2,6-Dichloropurine | HCID 5324412 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 2-Chloro-6-(3-fluoro-phenyl-amino)-purine | HCID 21988328 | — |
反応手順
2 g (10.58 mmol) of 2,6-dichloro-purine and 5.9 g (52.9 mmol) of 3-fluoro-aniline (Fluka, Buchs, Switzerland) are stirred in 60 ml of n-butanol and 3 ml of DMF at 80° C. for 5 h. The cooled reaction mixture is treated with isopropanol and the crystal mass which has precipitated out is filtered off and dried. 2-Chloro-6-(3-fluoro-phenyl-amino)-purine is obtained; m.p.>250° C.; FAB-MS: (M+H)+=264; Rf=0.3 (CH2Cl2:methanol 9:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091346B1 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-b882d8a91c4f492da930efef14481420 |
| 出典メモ | uspto-grants-2006_08 |