Acetone → Ethyl 2-[(4-ethoxyphenyl)sulfanyl]propanoate

HRID 991037ノート

反応式

HRID 991037 の反応式
[CH2:1]([O:3][C:4](=[O:15])[CH:5]([S:7][C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1)[CH3:6])[CH3:2].C([O-])([O-])=O.[K+].[K+].[CH3:22][C:23](C)=O>>[CH2:1]([O:3][C:4](=[O:15])[CH:5]([S:7][C:8]1[CH:9]=[CH:10][C:11]([O:14][CH2:22][CH3:23])=[CH:12][CH:13]=1)[CH3:6])[CH3:2]

参加物

4

反応物 3

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 109771882-[(4-Hydroxyphenyl)thio]propanoic acid ehtyl ester

生成物 1

HCID 10934051Ethyl 2-[(4-ethoxyphenyl)sulfanyl]propanoate

実験手順

To stired solution of 2-(4-hydroxy-phenylsulfanyl)-propionic acid ethyl ester (11.3 g, 50 mmol), and K2CO3 (50 g, excess) in acetone (300 ml) ethyl iodide (20 ml, excess) was added and refluxed for 8 hrs. At the end, reaction mixture was filtered and concentrated. The residue obtained was extracted with chloroform and washed well with water. It was dried and concentrated. The product, 2-(4-ethoxy-phenylsulfanyl)-propionic acid ethyl ester was isolated as colorless oil. Yield: 12.0 g, 98%; MS: 255 (M+H).

後処理

  1. temperaturerefluxed for 8 hrs
  2. customAt the end, reaction mixture
  3. filtrationwas filtered
  4. concentrationconcentrated
  5. customThe residue obtained
  6. extractionwas extracted with chloroform
  7. washwashed well with water
  8. customIt was dried
  9. concentrationconcentrated

出典と根拠

ORDレコード
ord-82cc8cd8350b432ab3f6529470e2b200
出典データセット
uspto-grants-2002_10
特許番号
US06462073B2

反応ノート

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