4-(2-Piperidin-1-yl-ethoxy)benzyl chloride → 2-Methyl-2-(2-methyl-furan-3-sulfonyl)-3-[4-(2-piperidin-yl-ethoxy)-phenyl]-propionic acid ethyl ester
反応式
[CH2:1]([O:3][C:4](=[O:16])[CH:5]([S:7]([C:10]1[CH:14]=[CH:13][O:12][C:11]=1[CH3:15])(=[O:9])=[O:8])[CH3:6])[CH3:2].Cl[CH2:18][C:19]1[CH:33]=[CH:32][C:22]([O:23][CH2:24][CH2:25][N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[CH:21][CH:20]=1>>[CH2:1]([O:3][C:4](=[O:16])[C:5]([CH3:6])([S:7]([C:10]1[CH:14]=[CH:13][O:12][C:11]=1[CH3:15])(=[O:8])=[O:9])[CH2:18][C:19]1[CH:33]=[CH:32][C:22]([O:23][CH2:24][CH2:25][N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[CH:21][CH:20]=1)[CH3:2]参加物
3
実験手順
2-Methyl-2-(2-methyl-furan-3-sulfonyl)-3-[4-(2-piperidin-yl-ethoxy)-phenyl]-propionic acid ethyl ester was prepared according to the general method as outlined in example 9. Starting from 2-(2-methyl-furan-3-sulfonyl)-propionic acid ethyl ester (2.4 g, 9.8 mmol) and 1-[2-(4-chloromethylphenoxy)-ethyl]-piperidine (2.96 g, 10.7 mmol); Yield 2.4 g (92%); amber oil; MS 464.2 (M+H)+.
出典と根拠
- ORDレコード
- ord-17b85030cc0d4fb2a29de1337567eb27
- 出典データセット
- uspto-grants-2002_10
- 特許番号
- US06462073B2
反応ノート
読み込み中…