1,3-Cyclohexanedione, 2-acetyl-5,5-dimethyl- → HCID 178475056、化合物

HRID 991151

反応式

HRID 991151 の反応式
[C:1]([NH:4][C@@H:5]1[C@@H:10]([O:11][C:12](=[O:14])[CH3:13])[C@H:9]([O:15][C:16](=[O:18])[CH3:17])[C@@H:8]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[O:7][C@H:6]1[NH2:24])(=[O:3])[CH3:2].[CH3:25][C:26]([CH:28]1[C:34](=[O:35])[CH2:33][C:32]([CH3:37])([CH3:36])[CH2:31][C:29]1=[O:30])=O>CO>[C:1]([NH:4][C@@H:5]1[C@@H:10]([O:11][C:12](=[O:14])[CH3:13])[C@H:9]([O:15][C:16](=[O:18])[CH3:17])[C@@H:8]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[O:7][C@H:6]1[NH:24][C:26](=[C:28]1[C:34](=[O:35])[CH2:33][C:32]([CH3:37])([CH3:36])[CH2:31][C:29]1=[O:30])[CH3:25])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 5194481,3-Cyclohexanedione, 2-acetyl-5,5-dimethyl-HCID 108933592-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-beta-D-glucopyranosylamine

生成物 1

HCID 178475056HCID 178475056、化合物収率 60%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosyl amine (80 mg, 0.23 mmol) and 2-acetyldimedone (55 mg, 0.30 mmol) in MeOH (5 ml) was refluxed for 5 h. The reaction mixture was evaporated, the residue was purified by chromatography using CHCl3/MeOH 10:0.5 as the mobile phase, to give 2-Acetamido-3,4,6-tri-O-acetyl-1,2-dideoxy-1-[1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethylamino]-β-D-glucopyranose (19) (70 mg, 60%).

後処理

  1. temperaturewas refluxed for 5 h
  2. customThe reaction mixture was evaporated
  3. customthe residue was purified by chromatography

出典と根拠

ORDレコード
ord-c83313feaa6a46669c5c196c4c767541
出典データセット
uspto-grants-2002_10
特許番号
US06462183B1

関連ノート

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