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Dimethylformamide → 2-Chloro-6-(3-trifluoromethyl-phenyl-amino)-purine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| 反応物 | 2,6-Dichloropurine | HCID 5324412 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 2-Chloro-6-(3-trifluoromethyl-phenyl-amino)-purine | HCID 21988237 | — |
反応手順
1.9 g (10 mmol) of 2,6-dichloro-purine are stirred in 60 ml of butanol and 3 ml of DMF with 8.05 g (50 mmol) of 3-amino-benzotrifluoride at 60° C. for 3 h. On cooling, 2-chloro-6-(3-trifluoromethyl-phenyl-amino)-purine is obtained as a crystalline mass. This is filtered off and dried in vacuo; m.p. 248° C.; FAB-MS: (M+H)+=314; Rf=0.45 (CH2Cl2:methanol=95:5).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091346B1 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-c8bd4d0a66984a0e969d11562e64778e |
| 出典メモ | uspto-grants-2006_08 |