Sodium Methoxide → HCID 22036378、化合物

HRID 991686ノート

反応式

HRID 991686 の反応式
Br[C:2]1[C:7]([O:8][CH2:9][CH2:10][OH:11])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][O-:13].[Na+]>CO>[OH:11][CH2:10][CH2:9][O:8][C:7]1[C:2]([O:13][CH3:12])=[N:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 220362632-[(2-Bromopyridin-3-yl)oxy]ethan-1-ol

生成物 1

HCID 22036378HCID 22036378、化合物収率 45%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of the product obtained in Step 1 (2.33 g, 10.7 mmol) and NaOMe (0.634 mg, 11.8 mmol) in MeOH (50 mL) was refluxed overnight. The reaction mixture was filtered and concentrated. The residue was purified by column chromatography on silica, using CH2Cl2/MeOH/heptane (4:1:5) as eluent, to give 0.81 g (45%) of the title compound as a colorless oil.

後処理

  1. temperaturewas refluxed overnight
  2. filtrationThe reaction mixture was filtered
  3. concentrationconcentrated
  4. customThe residue was purified by column chromatography on silica

出典と根拠

ORDレコード
ord-000a0d7b546a49cc933a6a158c28495c
出典データセット
uspto-grants-2002_10
特許番号
US06465467B1

反応ノート

読み込み中…