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4-Nitroaniline → 2-Chloro-6-(4-nitro-phenyl-amino)-purine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitroaniline | HCID 7475 | — |
| 反応物 | 2,6-Dichloropurine | HCID 5324412 | — |
| 溶媒 | DMF n-butanol | HCID 86623466 | — |
| 生成物 | 2-Chloro-6-(4-nitro-phenyl-amino)-purine | HCID 21988260 | — |
反応手順
1.9 g (10 mmol) of 2,6-dichloro-purine are stirred in 40 ml of DMF/n-butanol (1:3) with 4.1 g (30 mmol) of 4-nitro-aniline at 130° C. for 24 h and the crystal mass which precipitates out on cooling is filtered off and dried in vacuo. 2-Chloro-6-(4-nitro-phenyl-amino)-purine is obtained; m.p.>270° C.; FAB-MS: (M+H)+=291; Rf=0.6 (CH2Cl2:methanol=9:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091346B1 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-9d522069b2134617b6bccb18014497dc |
| 出典メモ | uspto-grants-2006_08 |