化工社化工社 化学情報印刷レポート · 研究参考用
p-Toluenesulfonic acid → Acrylamidomethyl 2-oxopyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Acrylamide | HCID 6579 | — |
| 反応物 | Phenothiazine | HCID 7108 | — |
| 反応物 | 1-(Methoxymethyl)-2-pyrrolidinone | HCID 13624830 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Acrylamidomethyl 2-oxopyrrolidine | HCID 18414899 | 40% |
反応手順
A mixture of 65.6 g of 1-methoxymethyl-2-pyrrolidone, 75.5 g of acrylarnide, 0.20 g of p-toluene sulfonic acid and 0.20 g of phenothiazine was stirred under N2 atmosphere at 150° C. for 1 hour, during which time the methanol was removed by distillation. The residue was cooled, and recrystallized from acetone to give the title compound in a yield of 40%. mp: 73-74° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06465588B1 |
| 出典データセット | uspto-grants-2002_10 |
| ORD ID | ord-2c4bf1dc13d9444a977d82b3489b7370 |
| 出典メモ | uspto-grants-2002_10 |