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Pentane → 3-Benzylcyclopentan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pentane | HCID 8003 | — |
| 反応物 | (S)-(-)-2,2'-Bis(di-p-tolylphosphino)-1, 1'-binaphthyl | HCID 4189906 | — |
| 反応物 | 3-Benzylcyclopent-2-en-1-one | HCID 11829917 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 3-Benzylcyclopentan-1-one | HCID 14400119 | 795.3% |
反応手順
General procedure B using (S)-p-tol-BINAP and 3-benzylcyclopentenone (0.11 g, 0.7 mmol) gave, after 24 h at 0° C. and flash chromatography (6:1 pentane:diethyl ether), the title compound as a clear liquid (0.97 g, 85% yield). Spectroscopic data were consistent with previously reported data for this compound.12 [α]D25° C.−96° (c 1.3, CHCl3). Chiral HPLC analysis (Chiracel OD column) indicated that the title compound was obtained in 96% ee.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06465664B1 |
| 出典データセット | uspto-grants-2002_10 |
| ORD ID | ord-8043dd963be74ac882008cdbdcd8c3d5 |
| 出典メモ | uspto-grants-2002_10 |