3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole → 5-Fluoro-3-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]cyclohex-1-enyl}-1H-indole

HRID 992048ノート

反応式

HRID 992048 の反応式
O1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[C:17]([F:20])[CH:18]=4)[NH:13][CH:12]=3)=[CH:7][CH2:6]2)OCC1.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:34][CH2:33][N:32](C2CCC(=O)CC2)[CH2:31][CH2:30]1>>[F:20][C:17]1[CH:18]=[C:19]2[C:14](=[CH:15][CH:16]=1)[NH:13][CH:12]=[C:11]2[C:8]1[CH2:9][CH2:10][CH:5]([N:32]2[CH2:31][CH2:30][N:29]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[O:22][CH3:21])[CH2:34][CH2:33]2)[CH2:6][CH:7]=1

参加物

3

反応物 2

HCID 105163803-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indoleHCID 105653074-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-cyclohexanone

生成物 1

HCID 102013125-Fluoro-3-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]cyclohex-1-enyl}-1H-indole

実験手順

This compound was prepared in the manner described above for intermediate 1c b y replacing 1,4-cyclohexanedione monoethylene ketal with 4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-cyclohexanone (1.44 g, 5 mmol). The crude mixture was used in next step without further purification.

後処理

  1. customThis compound was prepared in the manner
  2. customThe crude mixture was used in next step without further purification

出典と根拠

ORDレコード
ord-70bd21f3897f4d518c96c736f40bdae1
出典データセット
uspto-grants-2002_10
特許番号
US06465482B2

反応ノート

読み込み中…