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Adamantane → 1-Nitroadamantane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Adamantane | HCID 9238 | — |
| 反応物 | N-Hydroxyphthalimide | HCID 10665 | — |
| 反応物 | Nitric Oxide | HCID 145068 | — |
| 反応物 | Nitrogen Dioxide | HCID 178526396 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Benzonitrile | HCID 7505 | — |
| 生成物 | 1-Adamantanol | HCID 64152 | 6% |
| 生成物 | 1-Nitroadamantane | HCID 64165 | 68% |
反応手順
Into a flask, 1 mmole of adamantane, 0.1 mmole of N-hydroxyphthalimide, 2 ml of nitrogen dioxide (N2O), 6 ml of benzonitrile (6 ml) and 1.2 ml of acetic acid were added and stirred for 12 hours at 60° C. in an atmosphere of nitrogen monoxide (NO). The reaction products were analyzed by gas chromatography, and, as a result, the conversion of adamantane was 98%, nitroadamantane (yield 68%), adamantanol (yield 6%) and acetyloxyadamantane (yield 4%) were formed.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06468487B1 |
| 出典データセット | uspto-grants-2002_10 |
| ORD ID | ord-21b5cc6f392b455aa5422c0c24119d5f |
| 出典メモ | uspto-grants-2002_10 |