Potassium Bromide → 2-(Thiophen-2-yl)-1,3-thiazole-4-carbaldehyde
反応式
CC1(C)N([O])C(C)(C)CCC1.[K+].[Br-].[S:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[C:19]1[S:20][CH:21]=[C:22]([CH2:24][OH:25])[N:23]=1.Cl[O-].[Na+].C([O-])(O)=O.[Na+]>O.C(Cl)Cl>[S:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[C:19]1[S:20][CH:21]=[C:22]([CH:24]=[O:25])[N:23]=1参加物
8
実験手順
TEMPO (5.1 mg; 0.0329 mmol) and a solution of KBr (39.2 mg; 0.329 mmol) in water (0.5 ml) were added to a solution of (2-thiophen-2-ylthiazole-4-yl)methanol (0.65 g; 3.29 mmol) in CH2Cl2 (12 ml), followed, after cooling to 0-5° C., by dropwise addition of a solution of 7.1% sodium hypochlorite (4.1 ml; 4.1 mmol) and NaHCO3 (245 mg).
出典と根拠
- ORDレコード
- ord-39b93f7759374974b15ce23454ff4d93
- 出典データセット
- uspto-grants-2002_10
- 特許番号
- US06468979B1
反応ノート
読み込み中…
