(3S)-1-(2-Phenylethyl)-3-pyrrolidinamine → N-((S)-1-(2-phenylethyl)pyrrolidin-3-yl)-2-cyclopentylphenylacetamide
反応式
[CH:1]1([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[CH2:12][C:13]([OH:15])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:16][C@H:17]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:18]1>>[C:24]1([CH2:23][CH2:22][N:19]2[CH2:20][CH2:21][C@H:17]([NH:16][C:13](=[O:15])[CH2:12][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5]3)[CH2:18]2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1参加物
3
実験手順
2-Cyclopentylphenylacetic acid (0.39 g) and (S)-3-amino-1-(2-phenylethyl)pyrrolidine (0.3 g) were reacted under the same conditions as in Example 23 to give N-((S)-1-(2-phenylethyl)pyrrolidin-3-yl)-2-cyclopentylphenylacetamide (0.13 g), melting point 117-119° C.
出典と根拠
- ORDレコード
- ord-f7092631407848bbb1431641f3b4442d
- 出典データセット
- uspto-grants-2002_10