Bicyclo(2.2.1)heptane-7-carboxylic acid → (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-7-norbornanecarboxamide

HRID 992317

反応式

HRID 992317 の反応式
[CH:1]12[CH:7]([C:8]([OH:10])=O)[CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[NH2:11][C@H:12]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[CH2:13]1>>[F:25][C:22]1[CH:23]=[CH:24][C:19]([CH2:18][CH2:17][N:14]2[CH2:15][CH2:16][C@H:12]([NH:11][C:8]([CH:7]3[CH:4]4[CH2:3][CH2:2][CH:1]3[CH2:6][CH2:5]4)=[O:10])[CH2:13]2)=[CH:20][CH:21]=1

参加物

3

反応物 2

HCID 12757495Bicyclo(2.2.1)heptane-7-carboxylic acidHCID 59915932(S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine

生成物 1

HCID 59915874(S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-7-norbornanecarboxamide

実験手順

7-Norbornanecarboxylic acid and (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine were reacted under the same conditions as in Example 23 to give (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-7-norbornanecarboxamide.

出典と根拠

ORDレコード
ord-acc2faae6c8549d78b70838c21be1ca5
出典データセット
uspto-grants-2002_10
特許番号
US06468998B1

関連ノート

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