3,5-Dimethyl-1H-pyrrole-2-carbaldehyde → 3-[(2,3-Dimethylpyrrol-5-yl)methylene]-2-indolinone
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH3:11][C:12]1[CH:16]=[C:15]([CH3:17])[NH:14][C:13]=1[CH:18]=O>N1CCCCC1.C(O)C>[CH3:18][C:13]1[NH:14][C:15]([CH:17]=[C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][C:2]2=[O:10])=[CH:16][C:12]=1[CH3:11]参加物
5
反応条件
- 温度
- 90 °C
実験手順
A reaction mixture of 134.0 mg of oxindole, 147.8 mg of the 3,5-dimethylpyrrole-2-carboxaldehyde, and 3 drops of piperidine in 2 mL of ethanol was stirred at 90° C. for 3 h. After cooling, the precipitate was filtered, washed with cold ethanol, and dried to yield 136.7 mg (57%) of the title compound as a yellow solid.
後処理
- temperatureAfter cooling
- filtrationthe precipitate was filtered
- washwashed with cold ethanol
- customdried
出典と根拠
- ORDレコード
- ord-8abc047c059547c4a7c9f6a93d74c55f
- 出典データセット
- uspto-grants-2002_10
- 特許番号
- US06469032B2
反応ノート
読み込み中…