Tramadol → 2-((Dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol

HRID 992768ノート

反応式

HRID 992768 の反応式
[CH3:1][N:2]([CH2:4][C@@H:5]1[C@@:10]([OH:19])([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)[CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:3]>C(OCC)(=O)C>[CH3:3][N:2]([CH2:4][CH:5]1[C:10]([OH:19])([C:11]2[CH:12]=[C:13]([O:17][CH3:18])[CH:14]=[CH:15][CH:16]=2)[CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:1]

参加物

3

反応物 1

HCID 33741Tramadol

生成物 1

HCID 55232-((Dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
-2.5 °C

実験手順

A reactor vessel is charged successively with cis-Tramadol base hydrate (crude) 200 Kg and ethyl acetate 300 l and the contents of the vessel heated to 50° l C. until all solids are in solution. The vessel is then cooled to −5 to 0° C. and the product crystallises. Stirring is continued for two hours and the product is then centrifuged and washed with cold ethyl acetate, 2×25 l. Approximately 165-175 Kg (moist) of cis(+/−) Tramadol base hydrate are obtained from this procedure.

後処理

  1. temperaturethe contents of the vessel heated to 50° l C
  2. customthe product crystallises
  3. washwashed with cold ethyl acetate, 2×25 l

出典と根拠

ORDレコード
ord-e8c097f866f144beb1946a20b872bfee
出典データセット
uspto-grants-2002_10
特許番号
US06469213B1

反応ノート

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