Piperazine → N,N'-bis[[1-Methyl-3-(3,4,5-trimethoxy-phenyl)pyrazol-5-yl]methyl]piperazine

反応式

Cl[CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)[CH:4]=1.[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH3:8][N:7]1[C:3]([CH2:2][N:21]2[CH2:26][CH2:25][N:24]([CH2:2][C:3]3[N:7]([CH3:8])[N:6]=[C:5]([C:9]4[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=4)[CH:4]=3)[CH2:23][CH2:22]2)=[CH:4][C:5]([C:9]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)=[N:6]1

参加物

反応物 2

HCID 4837Piperazine

HCID 184084865-Chloromethyl-1-methyl-3-(3,4,5-trimethoxy-phenyl)pyrazole

生成物 1

HCID 10121602N,N'-bis[[1-Methyl-3-(3,4,5-trimethoxy-phenyl)pyrazol-5-yl]methyl]piperazine

実験手順

5-Chloromethyl-1-methyl-3-(3,4,5-trimethoxy-phenyl)pyrazole (119 mg) and piperazine (17 mg) were reacted in the same manner in Example 1 to obtain the title compound as a free base.

出典と根拠

ORDレコード: ord-a82ab5ba8c2b48d4932c5b5c2722a312
出典データセット: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06472386B1

反応ノート

読み込み中…