Ammonia → 3-amino-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

HRID 993152ノート

反応式

HRID 993152 の反応式
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([NH:8][C:9](=[O:14])[C:10]2([CH3:13])[O:12][CH2:11]2)=[CH:6][C:5]=1[C:17]([F:20])([F:19])[F:18])([O-:3])=[O:2].[NH3:21]>CO>[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([NH:8][C:9](=[O:14])[C:10]([OH:12])([CH3:13])[CH2:11][NH2:21])=[CH:6][C:5]=1[C:17]([F:20])([F:19])[F:18])([O-:3])=[O:2]

参加物

4

反応物 2

HCID 222AmmoniaHCID 140648402-Methyl-n-[4-nitro-3-(trifluoromethyl)phenyl]oxirane-2-carboxamide

生成物 1

HCID 100180753-amino-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide収率 58%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
-70 °C

実験手順

A pressure reactor was charged with 4-nitro-3-trifluoromethyl-N-[2,3-epoxy-2-methyl propionyl]aniline, BP-33, (10.0 g, 34.46 mmol) (see FIG. 3) and methanol (100 mL). After cooling to −70° C., ammonia in excess was condensed into the reactor which was sealed and stirred 14 hours. Following evaporation, the crude solid was washed with cold CH2Cl2 (50 mL). Filtration and drying gave 6.1 g BP-34 (58% yield).

後処理

  1. customcondensed into the reactor which
  2. customwas sealed
  3. customevaporation
  4. washthe crude solid was washed with cold CH2Cl2 (50 mL)
  5. filtrationFiltration
  6. customdrying
  7. customgave 6.1 g BP-34 (58% yield)

出典と根拠

ORDレコード
ord-4e6e7c77a9ef40098bb2364e07ce4106
出典データセット
uspto-grants-2002_10
特許番号
US06472415B1

反応ノート

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