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Hydrazine → 4-[6-(3-Amino-propyl)-pyridin-3-yl]-butyl amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine | HCID 9321 | — |
| 反応物 | 2-(3-{5-[4-(1,3-Dioxo-isoindol-2-yl)-butyl]-pyridin-2-yl}-propyl)-isoindole-1,3-dione | HCID 18408985 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-[6-(3-Amino-propyl)-pyridin-3-yl]-butyl amine | HCID 18408986 | 111.6% |
反応手順
A mixture of 3-4 (14 g, 30.7 mmol) and hydrazine (5 mL) in ethanol (500 mL) was heated at reflux for 5 hours. The mixture was cooled and concentrated to ⅓ volume, diluted with 300 mL MTBE, and filtered. The filtrate was concentrated to give 7.1 g of 3-5 as a brown oil, contaminated with a small amount of phthalhydrazide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06472403B2 |
| 出典データセット | uspto-grants-2002_10 |
| ORD ID | ord-165f3f74c3344296a55b0036b226de24 |
| 出典メモ | uspto-grants-2002_10 |