HCID 54427682、化合物 → 6-Bromo-4-diazomethyl-7-hydroxycoumarin
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12]C(=O)C)[O:8][C:7](=[O:16])[CH:6]=[C:5]2[CH:17]=[N+:18]=[N-:19]>CO.[Zn]>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][C:7](=[O:16])[CH:6]=[C:5]2[CH:17]=[N+:18]=[N-:19]参加物
4
実験手順
A mixture of 43.0 mg (0.133 mmol) of compound 21 and 154.6 mg (2.36 mmol) of Zn in MeOH (10 mL) was stirred at room temperature for 75 hours under a N2 atmosphere. Zn was removed by filtration and washed thoroughly with MeOH. The combined organic layer was evaporated to yield 37.5 mg (0.133 mmol, 100% yield) of compound 22. MS (ES, positive) 282.7, 284.7.
後処理
- customZn was removed by filtration
- washwashed thoroughly with MeOH
- customThe combined organic layer was evaporated
出典と根拠
- ORDレコード
- ord-86847a5d2bfc47c08c7a77c5fd660639
- 出典データセット
- uspto-grants-2002_10
- 特許番号
- US06472541B2
反応ノート
読み込み中…