HCID 22891997、化合物 → HCID 69940044、化合物

HRID 993435ノート

反応式

HRID 993435 の反応式
[CH2:1]([O:8]C([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][N:18]2[C:22]([CH2:23][N:24]3[CH:28]=[C:27]([C:29]([N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)=[O:30])[C:26]([C:37]4[C:46]5[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=5)[CH:40]=[CH:39][CH:38]=4)=[N:25]3)=[CH:21][N:20]=[CH:19]2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.[H][H]>CO.[C+4].[OH-].[Pd+2].[OH-].[OH-].[OH-].[OH-].[OH-]>[OH2:8].[NH3:11].[CH3:1][OH:8].[NH:11]1[CH2:12][CH2:13][CH:14]([CH2:17][N:18]2[C:22]([CH2:23][N:24]3[CH:28]=[C:27]([C:29]([N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)=[O:30])[C:26]([C:37]4[C:46]5[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=5)[CH:40]=[CH:39][CH:38]=4)=[N:25]3)=[CH:21][N:20]=[CH:19]2)[CH2:15][CH2:16]1

参加物

6

反応物 2

HCID 22891997HCID 22891997、化合物HCID 178418361HCID 178418361、化合物

生成物 2

HCID 69940044HCID 69940044、化合物収率 144.4%HCID 140995658HCID 140995658、化合物

試薬・触媒・溶媒 2

HCID 178420936HCID 178420936、化合物触媒HCID 887Methanol溶媒

実験手順

227 mg (0.36 mmol) of the compound prepared in Example 158 was dissolved in methanol, 20 mg of palladium hydroxide carbon was added thereto, and the mixture was reacted under 1 atm of hydrogen for 2 hours. After the reaction was completed, the mixture was filtered and the solvent therein was removed. The residue was subjected to silica gel column chromatography(eluent: ammonia water/methanol=15/85, v/v) to give 120 mg (0.26 mmol, Yield 74%) of the title compound.

後処理

  1. filtrationthe mixture was filtered
  2. customthe solvent therein was removed

出典と根拠

ORDレコード
ord-609d34d020a544c09ff8a043d3d4ad85
出典データセット
uspto-grants-2002_10
特許番号
US06472526B1

反応ノート

読み込み中…