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흉선원

Thymogen

HCID 100094
노트반응
기본 정보개요이름 및 식별자물성화학 및 산업관련 반응화합물 노트
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기본 정보

CAS
122933-59-9
표준 SMILES
N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
InChIKey
LLEUXCDZPQOJMY-AAEUAGOBSA-N
분자식
C16H19N3O5
평균 분자량
333.34 g/mol
단동위원소 질량
333.13247072

개요

Glu-Trp is a dipeptide composed of L-glutamic acid and L-tryptophan joined by a peptide linkage. It has a role as a metabolite, an antineoplastic agent, an immunomodulator and an angiogenesis modulating agent. It is functionally related to a L-glutamic acid and a L-tryptophan.

이름 및 식별자

우선 이름
Thymogen
IUPAC
(4S)-4-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid
현지명
흉선원
영어명
thymogen
분자식
C16H19N3O5
분자량
333.33916

이름 및 동의어

Oglufanide38101-59-6ThymogenGlutamyltryptophanalpha-Glu-TrpL-Tryptophan, L-alpha-glutamyl-L-alpha-Glu-L-Trpoglufanida4RHY598T5UNSC-334073DTXSID10924324NSC334073
이름 더 보기
흉선원GenowhiteAids095357Aids-095357Anti-spot peptide DipeptideAnti-spot peptide Dipeptide powder(4S)-4-[N-((1S)-1-Carboxy-2-indol-3-ylethyl)carbamoyl]-4-aminobutanoic acid
oglufanidumRefChem:167983DTXCID401353167H-Glu-Trp-OHGlu-trpL-glutamyl-L-tryptophanOglufanide [INN]Timogen

데이터베이스 식별자

CAS
122933-59-9、38101-59-6
PubChem CID
100094
DTXSID
DTXSID10924324
ChEMBL
CHEMBL2111029
ChEBI
CHEBI:73512
UNII
4RHY598T5U
Nikkaji
J895.715K

물성

구조 계산 물성

XLogP
-2.7
극성 표면적
146 Ų
수소 결합 공여자 수
5
수소 결합 수용자 수
6
회전 가능 결합 수
8
무거운 원자 수
24
형식 전하
0
복잡도
484

실험 및 물리화학적 성질

DrugsPharmaceuticals -> Listed in ZINC15
LogP-2.24
Physical DescriptionSolid

물리화학적 성질

InChI
InChI=1/C16H19N3O5/c17-11(5-6-14(20)21)15(22)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/s3
InChIKey
LLEUXCDZPQOJMY-PZILLZCRNA-N
SMILES
C(O)(=O)CC[C@H](N)C(N[C@H](C(O)=O)CC1C2=C(NC=1)C=CC=C2)=O |&1:5,9,r|

화학 및 산업

약리 정보

PharmacodynamicsOglufanide regulates the body's innate immune response to defeat invading germs and cancer cells. It may control or reverse the suppression of the immune system which the hepatitis virus uses to defeat our normally healthy defenses.
MeSH Pharmacological Classification · 4건

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

Agents counteracting or neutralizing the action of POISONS.

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.

응용 분야 · 1건

용도H-Glu-Trp-OH, has show to have potential antiangiogenic and immunomodulating activities. It inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis. This agent has also been reported to stimulate the immune response to hepatitic C virus and intracellular bacterial infections.

공급사32 곳

深圳市迈思立生物科技有限公司17549219037 17549219037 · [email protected]
Shandong Hanjiang Chemical Co., Ltd+86-0533-2066820 +8618369939125 · [email protected]
浙江华军药业有限公司0571-17315361885 17315361885 · [email protected]
中科华药(江苏)生物科技有限公司18020125070 · [email protected]
四川省维克奇生物科技有限公司18108052721 17743264324 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
Shanghai Getian Industrial Co., LTD+86-15373193816 · [email protected]
LEON (NANJING) BIOTECHNOLOGY CO., LTD.15051830413 · [email protected]
PT CHEM GROUP LIMITED+86-85511178; +86-85511178 · [email protected]
Chongqing jooe co., ltd+86-15223382610 · [email protected]
杭州固拓生物科技有限公司0571-88211921 13336126704 · [email protected]
Dingwang Technology (Wuhan) Co., Ltd.+undefined-27-2786652399 +undefined13627115097 · [email protected]
南京莱昂生物科技有限公司025-84523390 -127; 17705183659 · [email protected]
成都云希化工有限公司+86-17380623303 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
江苏淳辉医疗科技有限公司13913819195 · [email protected]
南京肽业生物科技有限公司025-58361106-805 15951641583 · [email protected]
Changsha MOL Changes Biotechnology Co., Ltd.+8619375158599 · [email protected]
Hebei Weimiao Import and Export Trade Co., Ltd.+86-19948166995 · [email protected]
杭州肽佳生物科技有限公司0571-87213919 15967184799 · [email protected]
南京美韬医药科技有限公司[email protected] · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-15350571055 · [email protected]
南京诺尔生物科技有限公司17768782665 17768782665 · [email protected]
zhuzhou dingcheng meihei comestic co.,ltd18873369619 · [email protected]
重庆博涛生物科技有限公司15223382610 · [email protected]
南京源肽生物科技有限公司13357818155 · [email protected]
ANHUI BYERSEN BIOTECH CO. LTD+86-15385096007 +86-17755058861 · [email protected]
HANGZHOU CLAP TECHNOLOGY CO.,LTD86-571-88216897,88216896 13588875226 · [email protected]
Hubei KDG Web Science&Technology Co., Ltd[email protected]
Biochem Technology Limited+86-18267419633 · [email protected]
厦门维健研方生物科技有限公司18020748636 13799798806 · [email protected]
Dideu Industries Group Limited+8617392712697 · [email protected]

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