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기본 정보
- CAS
63335-25-1- 표준 SMILES
O=C(CCCCCCCCc1ccc(O)c(O)c1)c1c(O)cccc1O- InChIKey
HCOZRFYGIFMIEX-UHFFFAOYSA-N- 분자식
- C21H26O5
- 평균 분자량
- 358.434 g/mol
- 단동위원소 질량
- 358.17802393
이름 및 식별자
- 우선 이름
- Malabaricone C
- IUPAC
- 1-(2,6-Dihydroxyphenyl)-9-(3,4-dihydroxyphenyl)nonan-1-one
- 현지명
- 말라바리콘C
- 영어명
- Malabaricone C
- 분자식
- C21H26O5
- 분자량
- 358.43
이름 및 동의어
말라바리콘CMalabaricone CMalabaricone C, 10 mM in DMSO1-(2,6-Dihydroxyphenyl)-9-(3,4-dihydroxyphenyl)-1-nonanone1-(2,6-dihydroxyphenyl)-9-(3,4-dihydroxyphenyl)nonan-1-one1-Nonanone, 1-(2,6-dihydroxyphenyl)-9-(3,4-dihydroxyphenyl)-lipid metabolism,Inhibitor,sphingomyelin synthase,SMS 1,diet,obesity,inhibit,Malabaricone C,SMS 2
데이터베이스 식별자
- CAS
63335-25-1- PubChem CID
- 100313
- DTXSID
DTXSID40212721- ChEMBL
CHEMBL524100- ChEBI
CHEBI:69015- UNII
- C9K53R3PRN
- Nikkaji
- J19.530H
물성
물리화학적 성질
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 25 mg/ml; · DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
- 물리적 상태
- 결정성 고체
- 색상
- White to off-white
- InChI
- InChI=1S/C21H26O5/c22-16-13-12-15(14-20(16)26)8-5-3-1-2-4-6-9-17(23)21-18(24)10-7-11-19(21)25/h7,10-14,22,24-26H,1-6,8-9H2
- InChIKey
- HCOZRFYGIFMIEX-UHFFFAOYSA-N
- SMILES
- C(C1=C(O)C=CC=C1O)(=O)CCCCCCCCC1=CC=C(O)C(O)=C1
화학 및 산업
응용 분야
개요Malabaricone C is a diarylnonanoid that has been found in Myristica and has diverse biological activities. It scavenges 59.9% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals when used at a concentration of 7 μg/ml. Malabaricone C is active against S. aureus, B. subtilis, and C. albicans in vitro (MICs = 2-32 μg/ml). It is cytotoxic to A549, HL-60, and MCF-7 cells (IC50s = 12.3, 46.1, and 10.8 μM, respectively). Malabaricone C inhibits sphingomyelin synthase 1 (SMS1) and SMS2 activity in cell lysates (IC50s = 3 and 1.5 μM, respectively). It decreases body weight gain, hepatic steatosis, and hepatic and plasma triglyceride levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 0.1% in the diet.
상·하류 제품 정보
상류 원료
공급사42 곳
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江苏永健医药科技有限公司17701422015
武汉众志诚生物技术有限公司13628624121 13628604890 · [email protected]
成都普睿法药物研发有限公司82633860 18982077548 · [email protected]
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