[N2-(N-글리실-L-히스티딜)-L-리시나토(2-)]구리

개요Copper tripeptide, also known as [N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper or GHK-Cu, is a naturally occurring tripeptide. It was first isolated from human plasma but can be found in saliva and urine. During wound healing, it may be freed from existing extracellular proteins via proteolysis. Studies have shown that GHK-Cu has a maximal biological effect at 10-9 mol/L and Its concentration in the body decreases with age[1].

용도Copper tripeptide (GHK-Cu) can be used as a skin antiaging agent. It could lead to the extracellular matrix accumulation increases in the rat wound model. Copper Peptide preparations were able to promote wound healing rates in diabetic ulcers and patients undergoing Mohs surgery. It could induce angiogenesis in rabbit models at 1012 mol/L by acting as a chemoattractant for capillary cells. It may also improve the autocrine growth factor milieu in keloid fibroblasts[1-2]. It can also be doped into It can also be doped into binary binary PBDB-T: ITIC to tune the crystallinity and phase separation of the active layer, improving the performance of polymer solar cells[3].