기본 정보
- CAS
627085-11-4- 표준 SMILES
CC1(C)CC(OC(=O)C2CC2)CC(C)(C)N1O- InChIKey
ZWEXEKJLDHNLLA-UHFFFAOYSA-N- 분자식
- C13H23NO3
- 평균 분자량
- 241.33 g/mol
- 단동위원소 질량
- 241.1677936
개요
OT-551 is a novel small molecule that is topically dosed in an eye drop and has the unique ability to penetrate cell membranes and reach both the front and the back of the eye. It is intended to treat Age-related macular Degeneration (AMD), and preclinical research results indicate additional uses for OT-551, including treatment of early stage and advanced dry age-related macular degeneration (AMD) by protecting against retina photoreceptor cell death and inhibiting angiogenesis, the growth of small blood vessels leading to the wet-form of AMD. A leading cause of vision loss, AMD affects approximately 10 million Americans.
이름 및 식별자
- 우선 이름
- Ot-551
- IUPAC
- (1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl) cyclopropanecarboxylate
- 영어명
- Cyclopropanecarboxylic acid, 1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl ester
- 분자식
- C13H23NO3
- 분자량
- 241.33
이름 및 동의어
OT-551627085-11-4DZ02S3A31NCyclopropanecarboxylic acid, 1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl ester1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl cyclopropanecarboxylateRefChem:168700UNII-DZ02S3A31NOT 551(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl) cyclopropanecarboxylate1-Piperidinyloxy, 4-[(cyclopropylcarbonyl)oxy]-2,2,6,6-tetramethyl-627085-14-7627085-11-4 (free base)
이름 더 보기
CPC551CPC-551CPC 551
OT-551 (free base)orb1699738SCHEMBL3692374CHEMBL4297313ZWEXEKJLDHNLLA-UHFFFAOYSA-NAKOS040749100DB05650CS-0025789
데이터베이스 식별자
- CAS
627085-11-4- PubChem CID
- 10131000
- ChEMBL
CHEMBL4297313- UNII
- DZ02S3A31N
물성
구조 계산 물성
- XLogP
- 1.9
- 극성 표면적
- 49.8 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 17
- 형식 전하
- 0
- 복잡도
- 303
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Listed in ZINC15
물리화학적 성질
- 끓는 점
- 318.4 · 318.4±31.0 °C(Predicted)
- 밀도
- 1.12 · 1.12±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 13.76 · 13.76±0.70(Predicted)
화학 및 산업
약리 정보
PharmacodynamicsOT-551, which has been shown to be a potent catalytic antioxidant, recently completed a Phase 1 safety and comfort study in healthy volunteers.
공급사4 곳
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
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