1,2-Diaminocyclohexane-N,N,N',N'-tetraacetic acid

This chemical does not meet GHS hazard criteria for 96.9% (63 of 65) of all reports.

Not Classified

Aggregated GHS information provided per 65 reports by companies from 3 notifications to the ECHA C&L Inventory.

Chemical: Glycine, N,N'-1,2-cyclohexanediylbis[N-(carboxymethyl)-

Glycine, N,N'-1,2-cyclohexanediylbis[N-(carboxymethyl)-: Does not have an individual approval but may be used under an appropriate group standard

Rho GTPases are activated by glucosylation (for example RhoA at Thr37). The toxins catalyze the transfer of a glucosyl moiety from UDP-glucose to the Rho GTPases. The covalent attachment of the glucose moiety to a conserved threonine within the effector region of the GTPases renders the Rho-GTPases functionally inactive. As a consequence, the actin cytoskeleton is disaggregated and this is accompanied by cell rounding and formation of an arborized morphology. (A341, A340)

Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases.