2'-O-Methyladenosine
AMI · (2R,3R,4R,5R)-5-(6-AMino-9H-purin-9-yl)-2-(hydroxyMethyl)-4-Methoxytetrahydrofuran-3-ol · 2'-OMe-A · OMe-rA · cordysinin B · 2’-0MeA · 2'-OMe A · 2'-OMe-rA
식별자 및 물리적 특성
| CAS No. | 2140-79-6 |
|---|---|
| 분자식 | C11H15N5O4 |
| 평균 분자량 | 281.272 g/mol |
| 단동위원소 질량 | 281.11240396 g/mol |
| SMILES | CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(N)ncnc21 |
| InChIKey | FPUGCISOLXNPPC-IOSLPCCCSA-N |
| PubChem CID | 102213 |
| ChEMBL | CHEMBL73237 |
| ChEBI | CHEBI:69426 |
| DTXSID | DTXSID50175671 |
화학 및 물리적 성질
| 녹는점 | 200-202 C |
|---|---|
| 끓는 점 | 623.8±65.0 °C(Predicted) |
| 밀도 | 1.84±0.1 g/cm3(Predicted) |
| 저장 조건 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 용해도 | DMSO(약간 용해됨), 메탄올(약간 용해됨, 가열, 초음파 처리), 물(약간 용해됨) |
| 물리적 상태 | 가루 |
| pKa(산도 계수) | 13.13±0.70(Predicted) |
| 색상 | 흰색에서 황백색까지 |
| 용해도 | 물에 용해됩니다. |
| InChI | InChI=1S/C11H15N5O4/c1-19-8-7(18)5(2-17)20-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1 |
| InChIKey | FPUGCISOLXNPPC-YGHVBYMHSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](OC)[C@@H]1O |
화학적 성질
White Solid
안전 및 규제
| 수질 위해 등급(WGK) | 3 |
|---|---|
| 관세 코드 | 29349990 |
| 위험 문구(R) | 36/37/38 |
| 위험 표시 | Xi |
| 안전 문구(S) | 26-36-24/25 |
용도
개요
2'-O-Methyladenosine (Cordysinin B) is a member of the class of adenosines that is adenosine in which the hydroxy group at position 2' is replaced by a methoxy group. It has been isolated from the mycelia of Cordyceps sinensis. It has a role as a fungal metabolite. It is a member of adenosines and an ether. It derives from an adenosine. analogue with antiviral properties, starting material for 2'-O'-methyl nucleotides. Potential metabolite of 2'-O-Me-cAMP.
용도
2'-O-Methyladenosine is an analog of adenosine used to prepare nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
일반 설명
The 2'-O-Methyladenosine (Am) was showed to be the first nucleotide adjacent to the N7-methylguanosine (m7G) cap and it can be further modified at the N6 position by methylation to generate N6,2’-O-dimethyladenosine (m6Am) (92% chance of being modified), where the structure of m7G5'ppp5'm6AmpNp comprises 20–30% of all the structures[1]. The 2'-O-methyladenosine (Am) modification displaying the lowest level in tumor tissues[2].