피롤로퀴놀린퀴논
피롤로퀴놀린퀴논 · PQQ · PPQ · METHOXATIN · PYRROLOQUINOLINE · Coenzyme PQQ · 1H-Pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylicacid, 4,5-dihydro-4,5-dioxo- · PQQ Cofactor, Pyrroloquinoline quinone, 4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid
식별자 및 물리적 특성
| CAS No. | 72909-34-3 |
|---|---|
| 분자식 | C14H6N2O8 |
| 평균 분자량 | 330.21 g/mol |
| 단동위원소 질량 | 330.01241515 g/mol |
| SMILES | O=C(O)c1cc(C(=O)O)c2c(n1)C(=O)C(=O)c1cc(C(=O)O)[nH]c1-2 |
| InChIKey | MMXZSJMASHPLLR-UHFFFAOYSA-N |
| PubChem CID | 1024 |
| ChEMBL | CHEMBL1235421 |
| ChEBI | CHEBI:18315 |
| EC No. | 839-691-6 |
| DTXSID | DTXSID3041162 |
| 현지명 | 피롤로퀴놀린퀴논 |
화학 및 물리적 성질
| XLogP | -0.1 |
|---|---|
| 극성 표면적 | 175 |
| 수소 결합 공여자 수 | 4 |
| 수소 결합 수용자 수 | 9 |
| 회전 가능 결합 수 | 3 |
| 무거운 원자 수 | 24 |
| 형식 전하 | 0 |
| 복잡도 | 647 |
| 의약품 | Pharmaceuticals -> Listed in ZINC15 |
| Physical Description | Solid |
| 녹는점 | 222 - 224°C |
| 끓는 점 | 1018.6±65.0 °C(Predicted) |
| 밀도 | 1.963±0.06 g/cm3(Predicted) |
| 저장 조건 | 2-8°C |
| 용해도 | DMSO(약간 용해됨), 메탄올(약간 용해됨) |
| pKa(산도 계수) | 1.88±0.20(Predicted) |
| 물리적 상태 | 고체 |
| 색상 | 주황색에서 빨간색으로 |
| 생물학적 소스 | synthetic |
| BRN | 3596812 |
| 안정성 | 빛과 온도에 민감함 |
| 화장품 원료 기능 | 피부 컨디셔닝보습제피부 보호항산화제 |
| InChI | InChI=1S/C14H6N2O8/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18/h1-2,15H,(H,19,20)(H,21,22)(H,23,24) |
| InChIKey | MMXZSJMASHPLLR-UHFFFAOYSA-N |
| SMILES | N1C2=C(C3NC(C(O)=O)=CC=3C(=O)C2=O)C(C(O)=O)=CC=1C(O)=O |
화학적 성질
Orange-Red Solid
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 50% (1 of 2) of reports.WarningH302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Acute Tox. 4 (50%) |
| 수질 위해 등급(WGK) | 3 |
| 관세 코드 | 29339900 |
| 안전 문구(S) | 22-24/25 |
| F 고인화성물질 | 8 |
| 저장 분류 | 11 - Combustible Solids |
용도
개요
Pyrroloquinoline quinone (PQQ) is a novel biofactor for which a proposition can be made for physiological importance. PQQ was first recognized as an enzyme cofactor in bacteria. It has recently been tentatively identified as a component of interstellar dust. Thus, PQQ may have been present throughout early biological conception and evolution. PQQ is also a potent plant growth factor. Consequently, for animals and humans, there has been constant exposure to PQQ. In animals, PQQ is reported to participate in a range of biological functions with apparent survival benefits (e.g., improved neonatal growth and reproductive performance). There are also benefits from PQQ supplementation related to cognitive, immune, and antioxidant functions, as well as protection from cardiac and neurological ischemic events. Although PQQ is not currently viewed as a vitamin, its involvement in cell signaling pathways, particularly those important to mitochondriogenesis in experimental animal models, may eventually provide a rationale for defining PQQ as vital to life. For humans, such evidence suggests there may be similar parallels or benefits from improving PQQ status.
용도
Pyrroloquinoline quinone is an important growth factor for the body and a redox/cofactor found in a a class of enzymes called quinoproteins. It is a cofactor of microbial quinoprotein enzyme, and imidazopyrroline. it regulates the level of free radicals in the body, protects the body; anti-oxidative damage; enhances mitochondrial function; detoxification; disease, etc.
일반 설명
PQQ is pyrroloquinoline quinone. It is sometimes called methoxatin, pyrroloquinoline quinone disodium salt, and a longevity vitamin. It is a compound made by bacteria and is found in fruits and vegetables.PQQ in bacteria helps them digest alcohol and sugar, which makes energy. This energy helps them survive and grow. Animals and plants don’t use PQQ the same way that bacteria do, but it is a growth factor that helps plants and animals grow. It also seems to help them tolerate stress.