피롤로퀴놀린퀴논

Pyrroloquinoline Quinone

HCID 1024CAS 72909-34-3

기본 정보

표준 SMILES
O=C(O)c1cc(C(=O)O)c2c(n1)C(=O)C(=O)c1cc(C(=O)O)[nH]c1-2
InChIKey
MMXZSJMASHPLLR-UHFFFAOYSA-N
분자식
C14H6N2O8
평균 분자량
330.21 g/mol
단동위원소 질량
330.01241515

개요

Pyrroloquinoline quinone is a pyrroloquinoline having oxo groups at the 4- and 5-positions and carboxy groups at the 2-, 7- and 9-positions. It has a role as an antioxidant, a cofactor, a water-soluble vitamin (role) and an anti-inflammatory agent. It is a member of orthoquinones, a pyrroloquinoline cofactor and a tricarboxylic acid. It is a conjugate acid of a pyrroloquinoline quinone(3-).

이름 및 식별자

우선 이름
Pyrroloquinoline Quinone
IUPAC
4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid
현지명
피롤로퀴놀린퀴논
영어명
Pyrroloquinoline quinone
분자식
C14H6N2O8
분자량
330.21

이름 및 동의어

pyrroloquinoline quinone72909-34-3methoxatinCoenzyme pqqPqq coenzymePqq cofactorPyrrolo-quinoline quinone4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid2,7,9-Tricarboxypyrroloquinoline quinone4,5-dioxo-1H,4H,5H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid2,7,9-Tricarboxy-1H-pyrrolo(2,3-f)quinoline-4,5-dionepyrroloquinolinedione tricarboxylic acid
이름 더 보기
피롤로퀴놀린퀴논PQQPPQPYRROLOQUINOLINE1H-Pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylicacid, 4,5-dihydro-4,5-dioxo-PQQ Cofactor, Pyrroloquinoline quinone, 4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acidPyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricChemicalbookarboxylicacid,Methoxatin,PQQPQQ98%PQQ CAS
DTXSID3041162CHEBI:1831547819QGH5L1H-Pyrrolo(2,3-f)quinoline-2,7,9-tricarboxylic acid, 4,5-dihydro-4,5-dioxo-2,4,6-tricarboxylic-pyrrolo[2,3-5,6]quinoline 8,9-quinoneCoenzyme, PQQCofactor, PQQPQQ, Coenzyme

데이터베이스 식별자

CAS
72909-34-3
PubChem CID
1024
DTXSID
DTXSID3041162
ChEMBL
CHEMBL1235421
ChEBI
CHEBI:18315
UNII
47819QGH5L
EC Number
839-691-6
Nikkaji
J126.218A

물성

구조 계산 물성

XLogP
-0.1
극성 표면적
175 Ų
수소 결합 공여자 수
4
수소 결합 수용자 수
9
회전 가능 결합 수
3
무거운 원자 수
24

실험 및 물리화학적 성질

DrugsPharmaceuticals -> Listed in ZINC15
Physical DescriptionSolid

물리화학적 성질

녹는점
222 · 222 - 224°C
끓는 점
1018.6 · 1018.6±65.0 °C(Predicted)
밀도
1.963 · 1.963±0.06 g/cm3(Predicted)
저장 조건
2 · 2-8°C
용해도
DMSO(약간 용해됨), 메탄올(약간 용해됨)
산도 계수 (pKa)
1.88 · 1.88±0.20(Predicted)

화학적 성질

Orange-Red Solid

안전 및 규제

GHS 분류

GHS Classification · 5건

This chemical does not meet GHS hazard criteria for 50% (1 of 2) of reports.

Warning

H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 4 (50%)

안전 데이터

wgk
3
HS 번호
29339900
safety_code
22-24/25
F 고인화성물질
8
스토리지 클래스
11 - Combustible Solids

화학 및 산업

약리 정보

Metabolite PathwaysAlkaptonuria
응용 분야 · 3건

개요Pyrroloquinoline quinone (PQQ) is a novel biofactor for which a proposition can be made for physiological importance. PQQ was first recognized as an enzyme cofactor in bacteria. It has recently been tentatively identified as a component of interstellar dust. Thus, PQQ may have been present throughout early biological conception and evolution. PQQ is also a potent plant growth factor. Consequently, for animals and humans, there has been constant exposure to PQQ. In animals, PQQ is reported to participate in a range of biological functions with apparent survival benefits (e.g., improved neonatal growth and reproductive performance). There are also benefits from PQQ supplementation related to cognitive, immune, and antioxidant functions, as well as protection from cardiac and neurological ischemic events. Although PQQ is not currently viewed as a vitamin, its involvement in cell signaling pathways, particularly those important to mitochondriogenesis in experimental animal models, may eventually provide a rationale for defining PQQ as vital to life. For humans, such evidence suggests there may be similar parallels or benefits from improving PQQ status.

용도Pyrroloquinoline quinone is an important growth factor for the body and a redox/cofactor found in a a class of enzymes called quinoproteins. It is a cofactor of microbial quinoprotein enzyme, and imidazopyrroline. it regulates the level of free radicals in the body, protects the body; anti-oxidative damage; enhances mitochondrial function; detoxification; disease, etc.

일반 설명PQQ is pyrroloquinoline quinone. It is sometimes called methoxatin, pyrroloquinoline quinone disodium salt, and a longevity vitamin. It is a compound made by bacteria and is found in fruits and vegetables.PQQ in bacteria helps them digest alcohol and sugar, which makes energy. This energy helps them survive and grow. Animals and plants don’t use PQQ the same way that bacteria do, but it is a growth factor that helps plants and animals grow. It also seems to help them tolerate stress.

공급사50 곳

郑州阿尔法化工有限公司+86-18530059196 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Shanghai Biolang Biotechnology Co., Ltd.+86-15970428662 +86-13397199602 · [email protected]
西安江林生物科技有限公司18292036798; 18292036798
河北创海生物科技有限公司+86-86-13131129325 · [email protected]

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2건

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