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기본 정보
- CAS
116457-99-9- 표준 SMILES
CCCCCCCCCCCCCCCCSC[C@H](COP(=O)(O)OCC[N+](C)(C)C)NC(=O)CCCCCCCCCCCCCCC- InChIKey
WLWWVTPUDQTUJU-KDXMTYKHSA-O- 분자식
- C40H84N2O5PS+
- 평균 분자량
- 736.162 g/mol
- 단동위원소 질량
- 735.58330784
이름 및 식별자
- 우선 이름
- Thioetheramide PC
- IUPAC
- (7S)-7-[(Hexadecylsulfanyl)methyl]-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-3,5-dioxa-8-aza-4lambda~5~-phosphatetracosan-1-aminium
- 현지명
- 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-글리세로-3-포스포콜린
- 영어명
- 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE
- 분자식
- C45H93N2O4PS
- 분자량
- 789.27
이름 및 동의어
1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-글리세로-3-포스포콜린THIOETHERAMIDE PCWLWWVTPUDQTUJU-KDXMTYKHSA-NThioetheramide phosphorylcholine1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE1-PALMITYLTHIO-2-PALMITOYLAMINO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE1,2-DIDEOXY-1-(S-HEXADECYL)THIO-2-(N-HEXADECANOYL)AMINO-SN-GLYCERYL-3-PHOSPHORYLCHOLINE3,5-Dioxa-9-thia-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-7-[(1-oxohexadecyl)amino]-, inner salt, 4-oxide, (7S)-
데이터베이스 식별자
- CAS
116457-99-9- PubChem CID
- 10259407
- DTXSID
DTXSID60437378- Nikkaji
- J562.285I
물성
물리화학적 성질
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- Soluble in DMSO;Soluble in dimethyl formamide
- 물리적 상태
- 백색 고체.
화학 및 산업
응용 분야
개요Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). The IC50 value for thioetheramide-PC is 2 μM at a substrate concentration of 0.5 mM. In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.
공급사10 곳
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
BOC Sciences16314854226 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
Aladdin Scientific[email protected]
ChemeGen 中国18818260767 · [email protected]
上海甄准生物科技有限公司18019219489 18901678489 · [email protected]
广州优南科技有限公司020-82000279 18988941452 · [email protected]
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