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기본 정보
- CAS
853625-60-2- 표준 SMILES
COc1nc(-c2ccc3c(c2)OCO3)n(-c2ccc(NC(=O)CSc3ccccc3)cc2)n1- InChIKey
QPGYAMIHXLCFTJ-UHFFFAOYSA-N- 분자식
- C24H20N4O4S
- 평균 분자량
- 460.515 g/mol
- 단동위원소 질량
- 460.12052612
이름 및 식별자
- 우선 이름
- SecinH3
- IUPAC
- N-{4-[5-(2H-1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl}-2-(phenylsulfanyl)acetamide
- 영어명
- N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE
- 분자식
- C24H20N4O4S
- 분자량
- 460.51
이름 및 동의어
SECINH3CS-2379N-(4-(5-(benzo[d][1SecinH3, 10 mM in DMSOSecinH3, Sec7-GEF inhibitor3]dioxol-5-yl)-3-methoxy-1H-14-triazol-1-yl)phenyl)-2-(phenylthio)acetamideN-[4-[5-(1,3-benzodioxol-5-yl)-3-methoxy-1,2,4-triazol-1-yl]phenyl]-2-phenylsulfanylacetamideN-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDEAcetamide, N-[4-[5-(1,3-benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)-
데이터베이스 식별자
- CAS
853625-60-2- PubChem CID
- 1029232
- DTXSID
DTXSID80359866- ChEMBL
CHEMBL1731533- ChEBI
CHEBI:92787- EC Number
- 418-180-8
- Nikkaji
- J2.393.557K
물성
물리화학적 성질
- 저장 조건
- 2 · Inert atmosphere,2-8°C
- 용해도
- 30 mg/ml; · DMF: 30 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 25 mg/ml; Ethanol: 0.3 mg/ml
- 물리적 상태
- 백색 분말 고체.
- 색상
- White to off-white
- InChI
- 1S/C24H20N4O4S/c1-30-24-26-23(16-7-12-20-21(13-16)32-15-31-20)28(27-24)18-10-8-17(9-11-18)25-22(29)14-33-19-5-3-2-4-6-19/h2-13H,14-15H2,1H3,(H,25,29)
- InChIKey
- QPGYAMIHXLCFTJ-UHFFFAOYSA-N
- SMILES
- S(CC(=O)Nc2ccc(cc2)[n]3nc(nc3c4cc5c(cc4)OCO5)OC)c1ccccc1
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- WGK 1
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
용도SecinH3 is a Sec7 cytohesin inhibitor.
일반 설명A cell-permeable triazolo compound that acts as a Sec7 domain-binding (Kd ≤250 nM for Sec7 from human cytohesins 1-3), selective antagonist against cytohesin family small GEFs (IC50 ≤5.6 μM in ARF1 GDP/GTP exchange assays using human cytohesin 3, as well as murine and Drosophila homologues). It inhibits large GEFs only at much higher concentrations (IC50 ≥65 μM in GDP/GTP exchange assays using hEFA6-S7 and yGea2-S7) and exhibits little activity against a panel of 10 commonly studied kinases or hSosII. Shown to effectively inhibit insulin signaling both in HepG2 cells in vitro and in Drosophila and mice in vivo.
공급사47 곳
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
上海波以尔化工有限公司[email protected]
大连美仑生物技术有限公司0411-62910999 13889544652 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
InvivoChem中国13549236410 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
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